Study of pegloticase with methotrexate for uncontrolled gout
Treatments studied
Part of Bones, joints & muscles clinical trials.
This trial tests a new way of giving pegloticase (a drug that breaks down uric acid) by injection under the skin, combined with methotrexate, to see if it works better for people with uncontrolled gout. It might help if you have painful flares that don't go away with usual treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have gout that is not well controlled with current treatments.
- You must be at least 18 years old.
- You cannot have had pegloticase or a similar uricase drug before.
- You must be willing and able to take methotrexate along with the study drug.
- You must not have severe kidney disease (eGFR below 40) or be on dialysis.
- You must be able to take at least one gout flare medication (like colchicine or ibuprofen).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This early-phase trial tests a new injectable medication (Peguricase) combined with methotrexate to lower uric acid in people with gout that standard pills haven't controlled. You would first take a low dose of methotrexate to check your tolerance, then receive Peguricase infusions while stopping your usual gout medications.
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This study tests a new drug called IN026 for people with refractory gout—gout that doesn't respond well to current treatments and causes severe symptoms. The goal is to see if IN026 can lower uric acid levels and reduce gout attacks.
This trial tests an injectable drug called pegtibatinase for people with a rare condition called homocystinuria. It aims to lower high levels of homocysteine in the blood compared to a placebo, while you continue your usual treatments.
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