Peguricase with methotrexate for uncontrolled gout
Treatments studied
Part of Bones, joints & muscles, Genetic & congenital, Hormones & metabolism clinical trials.
This early-phase trial tests a new injectable medication (Peguricase) combined with methotrexate to lower uric acid in people with gout that standard pills haven't controlled. You would first take a low dose of methotrexate to check your tolerance, then receive Peguricase infusions while stopping your usual gout medications.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have uncontrolled gout, meaning your uric acid stays high despite standard treatments, or you cannot take those treatments.
- You must be willing to stop all other uric-acid-lowering drugs for at least 7 days before starting methotrexate.
- You must be able to tolerate a test dose of methotrexate during a short run-in period before the main study.
- You do not have serious medical conditions like active infections, liver or kidney disease, uncontrolled diabetes or blood pressure, heart problems, or a recent history of cancer.
- You have no known allergies to the study drugs (methotrexate, pegloticase, or rescue medications) and have not taken pegloticase before.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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