Study of a clot-busting drug before thrombectomy for stroke
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests giving a clot-dissolving medicine (rhPro-UK) through a vein before a procedure to remove a large blood clot in the brain. It is for people who had a stroke 4.5 to 24 hours ago and are already scheduled for clot removal. The goal is to see if the medicine helps improve blood flow and outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years of age or older.
- You had a sudden loss of brain function (stroke) from a blocked artery, and it has been between 4.5 and 24 hours since you were last seen well.
- Before this stroke, you were able to live independently (no major disability).
- Your stroke symptoms are severe, with a score of 6 or higher on a standard stroke scale.
- Brain imaging shows a large artery blockage in a specific location and signs that some brain tissue can still be saved.
- You are already scheduled to have a procedure (thrombectomy) to remove the clot.
- You or your legal representative can sign a consent form.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a clot-busting drug called pro-urokinase can help people with a stroke in the back of the brain when given later than usual (4.5 to 9 hours after symptoms start). The goal is to see if it improves recovery and reduces disability.
This trial tests whether giving a clot-dissolving medication directly into the brain's blood vessels during a standard procedure (mechanical thrombectomy) can improve outcomes for people with a stroke caused by a blockage in a medium-sized artery. It may be an option for patients who arrive at the hospital within 24 hours of symptom onset and have enough salvageable brain tissue.
This study tests a clot-busting medicine given through an IV to people who had a stroke caused by a blocked medium-sized blood vessel in the brain, and who can be treated 4.5 to 24 hours after symptoms start. The goal is to see if it improves recovery and reduces disability compared to standard care.
This trial compares two clot-busting drugs (tenecteplase or reteplase) given through an IV before a procedure to mechanically remove the clot (thrombectomy) in people with acute ischemic stroke. It aims to see which drug works better to restore blood flow and improve recovery.
This trial tests if removing a large blood clot from the brain up to 3 days after a stroke improves recovery compared to standard medical care alone. It is for patients who have a severe stroke and are otherwise healthy enough for the procedure.
This trial tests whether a clot-dissolving drug called tenecteplase can improve recovery for people who had a large-vessel ischemic stroke 4.5 to 24 hours earlier and can’t have a mechanical clot removal procedure in time. If you join, you’ll get either tenecteplase or standard medical care, and the study will track your recovery and safety.
Hear when a new Acute Ischemic Stroke trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.