Comparing two clot-busting drugs before mechanical clot removal in acute stroke
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial compares two clot-busting drugs (tenecteplase or reteplase) given through an IV before a procedure to mechanically remove the clot (thrombectomy) in people with acute ischemic stroke. It aims to see which drug works better to restore blood flow and improve recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had an acute (sudden) ischemic stroke (a block in a blood vessel in your brain, not bleeding) that started within the last 4.5 hours.
- You have a blockage in one of the large arteries in your brain (the internal carotid or middle cerebral artery).
- You are at least 18 years old.
- You have a certain score on a brain scan (CT or MRI) called ASPECTS, which measures how much brain tissue is still healthy. You need a score of 6–10 (out of 10).
- You have not had bleeding in the brain, and you are not expected to have a terminal illness (life expectancy over 1 year).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving a clot-busting drug (tenecteplase) before transferring you to a hospital that can do a procedure to remove the clot improves outcomes for people who had a stroke up to 24 hours earlier. You may qualify if you have a blockage in a large artery in the front of your brain and can still get the procedure.
This trial tests whether a clot-dissolving drug called tenecteplase can improve recovery for people who had a large-vessel ischemic stroke 4.5 to 24 hours earlier and can’t have a mechanical clot removal procedure in time. If you join, you’ll get either tenecteplase or standard medical care, and the study will track your recovery and safety.
This trial tests a new medication called rhTNK-tPA for treating acute ischemic stroke (a clot in the brain) up to 24 hours after symptom onset. The study uses simplified imaging to determine eligibility and aims to help patients recover better outcomes.
This trial tests giving a clot-dissolving medicine (rhPro-UK) through a vein before a procedure to remove a large blood clot in the brain. It is for people who had a stroke 4.5 to 24 hours ago and are already scheduled for clot removal. The goal is to see if the medicine helps improve blood flow and outcomes.
This trial tests a clot-busting drug called tenecteplase given later than usual (4.5 to 9 hours after stroke symptoms) to people whose MRI shows the stroke may still be reversible. The goal is to see if it helps reduce disability after a stroke.
This trial tests whether giving a clot-busting drug (alteplase) directly into the brain artery after a successful clot removal improves recovery in people with severe stroke. It is for patients who have had a thrombectomy and still have a large blocked artery in the front of the brain.
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