Macitentan for chest pain from small heart vessel issues
Treatments studied
Part of Heart & circulation clinical trials.
This study tests a medicine called macitentan to see if it helps people with chest pain caused by problems in the tiny heart blood vessels (not from big blockages). If you have angina but no major artery blockages, this trial might explore a new treatment option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have typical chest pain or discomfort (angina).
- Your heart arteries are not severely blocked (a test showed less than 50% narrowing).
- You have had a special test to check the tiny blood vessels in your heart.
- You are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if mactientan, a blood vessel relaxer, can improve chest pain in people with coronary microvascular angina—where small heart arteries don't work right even though larger ones are clear. It aims to help those with ongoing angina symptoms.
This trial tests a special wireless pressure catheter to see how well the tiny blood vessels in the heart are working. It may help people who have chest pain but don't have major blockages in their main heart arteries.
This trial studies people who have chest pain (angina) due to problems with the heart’s small arteries, not a big blockage. It aims to test whether treatment approaches can help these patients by better understanding the cause of their heart-related symptoms.
This trial tests whether a small pressure-reducing device placed in a heart vein (the coronary sinus) can reduce symptoms in people with ongoing chest pain from tiny blood vessel problems. It is for angina that has not improved despite standard heart medicines, and only if special heart tests show reversible reduced blood flow.
This study tests if specific heart medicines (like beta-blockers or calcium channel blockers) can help people with chest pain that is not caused by blocked arteries. It aims to treat the tiny blood vessels or spasms that may be the real cause of your pain.
This study tests whether a medication called vericiguat can improve chest pain caused by problems in the tiny blood vessels of the heart (not by large blockages). You may be a candidate if you have stable chest pain, are 40–75, and have had tests showing your heart's small vessels aren't working well.
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