Chemo injection before surgery for recurrent throat cancer
Treatments studied
Part of Cancer clinical trials.
This trial tests injecting a chemotherapy drug (cisplatin with epinephrine) directly into throat tumors, given once a week for 3 weeks before planned surgery. It is for people whose throat cancer has come back after radiation and who need surgery to remove it.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You had radiation therapy for laryngeal (voice box) cancer in the past.
- Your throat cancer has come back, proven by biopsy, and you need surgery.
- You are willing to get 3 weekly injections of the study drug while awake (a mild sedative is allowed).
- You have adequate kidney, liver, and blood cell counts tested within the past 6 weeks.
- You agree to avoid pregnancy for the study duration and 14 months after the last dose.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests adding an immunotherapy drug (PD-1 inhibitor) to chemotherapy before surgery for advanced laryngeal or hypopharyngeal cancer. The goal is to see if this combination shrinks tumors more and improves outcomes for patients who need their entire voice box removed.
This trial tests giving a combination of an immunotherapy drug (PD-1 inhibitor) and chemotherapy before surgery for people whose throat cancer has come back after initial treatment. The goal is to see if this approach can shrink the tumor and improve outcomes.
This trial tests whether giving a type of immunotherapy (PD-1 inhibitor) together with chemotherapy before surgery can help treat advanced laryngeal and hypopharyngeal squamous cell carcinoma. It aims to improve outcomes for patients whose cancer hasn't spread to distant organs.
This trial tests a new approach to treat throat cancer while trying to preserve your larynx (voice box). It combines chemotherapy drugs and an immunotherapy drug before surgery or radiation. The goal is to see if this can help you avoid needing to have your larynx removed.
This trial tests whether adding immunotherapy before surgery, followed by either radiation or organ-preserving surgery, can improve outcomes for people with locally advanced laryngeal or hypopharyngeal cancer. It may help avoid complete removal of the voice box.
This trial tests giving chemotherapy combined with an immunotherapy drug (finotonlimab) before surgery for locally advanced hypopharyngeal cancer. It aims to shrink the tumor enough to improve surgery outcomes.
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