Virus injection for children with recurrent brain tumors
Treatments studied
Part of Cancer clinical trials.
This trial is testing a virus called DNX-2401, which is injected directly into the tumor, for children and young adults with high-grade brain tumors that have come back or are hard to treat. The goal is to see if this virus can shrink or control the tumor.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a high-grade brain tumor (like glioblastoma, medulloblastoma, or ependymoma) that has come back or is not responding to treatment and cannot be fully removed by surgery.
- You are between 1 and 25 years old.
- You have at least one tumor that is bigger than about 1 cm and can be safely injected with a needle through a small hole in the skull.
- You are in fairly good health, can take care of yourself, and your blood counts, kidney, and liver function are adequate.
- You have not had chemotherapy, immunotherapy, or radiation to the whole brain or spine within the last 4–6 weeks, and you are off or on a low, stable dose of steroids.
- If you are sexually active, you agree to use birth control for at least 3–4 months after treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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