Clin2
NCT07444619Possibly a fitRecruiting

Combination drugs for returning soft tissue sarcoma in young people

Soft Tissue Sarcomas

Treatments studied

Part of Cancer clinical trials.

This trial tests if combining four drugs (pazopanib, trabectedin, ipilimumab, and nivolumab) can help treat soft tissue sarcomas that have come back. It is for children and young adults up to age 30.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
18 people
Ages
1 year to 30 years
Study type
Interventional

Who can take part

  • Be between 1 and 30 years old
  • Have a soft tissue sarcoma that has come back or is not responding to treatment
  • Have disease that can be seen on scans or exams
  • Be recovered from side effects of past treatments (like chemo or radiation)
  • Have acceptable blood counts, kidney, and liver function
  • Not be pregnant or breastfeeding

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06514313Recruiting· Phase 2
Study of a drug combo for children with returning soft tissue sarcoma

This trial tests a combination of three drugs (VIM and VIT) for children and young adults whose soft tissue sarcoma has come back or not responded to previous treatments. The goal is to see if this new combination can help shrink or control the tumor.

Guangzhou, Guangdong
NCT07457775Not yet recruiting· Phase 2
Combination drug therapy for advanced soft tissue sarcoma

This trial tests a combination of three drugs—liposomal irinotecan, temozolomide, and bevacizumab—for people with advanced soft tissue sarcoma that has spread or cannot be removed by surgery and has not responded to previous treatments. The goal is to see if this combination can help control the cancer.

Hangzhou, Zhejiang
NCT07612098Not yet recruiting· Phase 2
Radiation and drug combo before surgery for soft tissue sarcoma

This trial tests a combination of radiation therapy and two drugs (anlotinib and penpulimab) given before surgery for soft tissue sarcoma. The goal is to see if this approach can shrink tumors and improve outcomes.

Beijing, Beijing Municipality
NCT05679921Recruiting· Phase 2
Pazopanib, with or without pembrolizumab, for metastatic soft-tissue cancer

This Phase 2 trial tests pazopanib alone or together with pembrolizumab to slow or shrink metastatic soft-tissue sarcoma after prior chemotherapy. It may help some people by strengthening the anti-cancer effect compared with pazopanib by itself.

Seoul
NCT05774275Recruiting· Phase 1/Phase 2
Testing combined radiation, chemotherapy, and immunotherapy for high-risk sarcoma

This study tests whether giving radiation, chemotherapy, and immunotherapy together can control high-risk soft tissue sarcoma that is hard to remove or may come back after surgery. It may help by attacking cancer in different ways, including boosting the immune system.

Shanghai, Shanghai Municipality
NCT03138161Recruiting· Phase 1/Phase 2
Testing three medicines for previously treated soft-tissue sarcoma

This trial tests trabectedin plus ipilimumab and nivolumab in people with advanced soft-tissue sarcoma that has already been treated. It aims to see how well this combination works and how safely it can be given.

Santa Monica, California

Hear when a new Soft Tissue Sarcomas trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.