Catheter ablation for advanced atrial fibrillation
Part of Heart & circulation clinical trials.
This trial tests a special type of catheter ablation (using electric pulses called electroporation) to treat people with long-lasting atrial fibrillation and a very enlarged left atrium. It may offer a new treatment option when standard approaches are limited.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have persistent or long-standing persistent atrial fibrillation (a heart rhythm problem that lasts a long time).
- Your left atrium (one of the heart's upper chambers) is severely enlarged (measured by an imaging test as LAVI > 50 ml/m2).
- You are age 80 or younger.
- You have not had any previous ablation (a procedure that scars heart tissue to stop abnormal signals) in your left atrium.
- You do not have a blood clot in your left atrium, severe valve disease needing surgery, or a life-threatening condition.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests a heart rhythm procedure that uses electrical mapping to guide ablation (controlled scarring) of a specific area in the heart's left upper chamber to treat persistent atrial fibrillation—a condition where the heart beats irregularly for more than a week at a time. The goal is to see if this targeted approach helps restore normal heart rhythm.
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