Clin2
NCT07448298Possibly a fitWithdrawn

Testing AFN50 for hard-to-treat autoimmune diseases

Relapsed/Refractory Autoimmune Diseases

Part of Immune system & allergy clinical trials.

This study tests an experimental drug called AFN50 for people with certain autoimmune diseases that have not responded to standard treatments. It aims to see if AFN50 can help control the disease.

Summary written for real people, not researchers, by Clin2.

Phase
Early Phase 1
Ages
18 years to 69 years
Study type
Interventional

Who can take part

  • You are between 18 and 69 years old.
  • You have one of these autoimmune diseases that hasn't gotten better with standard treatments: lupus, Sjögren's syndrome, myasthenia gravis, systemic sclerosis, inflammatory myopathy, or ANCA vasculitis.
  • You have had active disease symptoms for at least 6 months, even while on medications like steroids or immunosuppressants.
  • Your organ functions (blood counts, liver, kidneys, heart, lungs) meet certain minimum levels.
  • You are not pregnant or breastfeeding, and agree to use birth control for 12 months after treatment.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07605637Not yet recruiting
Early study of a new treatment for autoimmune disease

This study tests a new treatment (STR-P005) for autoimmune diseases. It aims to selectively target and deplete B cells that carry a specific marker, CD19, which may help reduce disease activity.

NCT07655453Not yet recruiting
Early safety study of an investigational B cell treatment

This study tests an experimental drug called STR-P005 for people with diseases that affect B cells, such as certain autoimmune or blood disorders. The goal is to see if the drug is safe and if it helps reduce your disease symptoms.

NCT07816341Not yet recruiting· Phase 1
Study of a new drug for hard-to-treat autoimmune hemolytic anemia

This trial tests a new medicine for people with autoimmune hemolytic anemia (AIHA) that has not improved with standard treatments. The goal is to see if the drug can help control the disease and improve red blood cell counts.

Tianjin, Tianjin Municipality
NCT07408336Recruiting· Early Phase 1
Study of AFN50 injection for active lupus

This study tests an investigational injection called AFN50 for people whose lupus (SLE) remains active despite standard treatments. The goal is to see if the drug can safely help control lupus symptoms better than current therapies alone.

Hefei, Anhui
NCT06243159Not yet recruiting· Early Phase 1
Experimental injection for hard-to-treat autoimmune diseases

This early-phase trial is testing an experimental injection called JY231 for people with certain autoimmune diseases like lupus and scleroderma that haven't improved with standard treatments. The aim is to see if this treatment can reduce disease activity and improve symptoms.

Taiyuan, Shanxi
NCT07144462Recruiting· Early Phase 1
Testing a new drug for people with certain autoimmune diseases that have come back or not responded to treatment

This trial is testing a new injection, NEUK203-215, in adults aged 18-65 with certain autoimmune diseases (like lupus, scleroderma, inflammatory myopathy, or a skin blistering condition) that have relapsed or not responded to standard therapy. The goal is to see if it is safe, tolerable, and may help control the disease.

Shanghai, Shanghai Municipality

Hear when a new Relapsed/Refractory Autoimmune Diseases trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.