Inhaled isoflurane for hard-to-sedate ICU patients
Treatments studied
This trial provides access to an inhaled sedative (isoflurane) for ICU patients who are on a breathing tube and cannot be safely sedated with standard IV medicines. It aims to help patients who are agitated, need high doses of sedatives, or have side effects from current sedation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You are on a breathing machine (ventilator) in the ICU and need continuous sedation.
- Standard IV sedatives are not working well enough to keep you calm and safe, despite trying different combinations or doses.
- You have had episodes of agitation, tried to pull out your breathing tube or IV lines, or needed physical restraints.
- Your sedative and painkiller doses are increasing, or you have side effects from current sedation (like high triglycerides, slow heart rate, or withdrawal).
- Other sedative options are not suitable for you, and you are not in another study that prevents this expanded access.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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