Clin2
NCT07467590Possibly a fitNot yet recruiting

Combination radiotherapy and drugs for advanced colorectal cancer

Refractory Colorectal CancerRadiotherapy-Induced Immune PrimingImmune Response

Part of Cancer, Digestive system clinical trials.

This trial tests a new combination of high and low-dose radiation with immunotherapy and a targeted drug for advanced colorectal cancer that has not responded to previous treatments. The goal is to see if this approach can help shrink tumors and improve outcomes.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
33 people
Ages
18 years to 80 years
Study type
Interventional

Who can take part

  • You are between 18 and 80 years old.
  • You have colorectal cancer that has spread to other parts of the body (stage IV).
  • Your cancer has grown after at least one or two prior chemotherapy treatments.
  • You have at least two measurable tumors, with one at least 2 cm and another smaller than 2 cm.
  • You are able to take oral medications and are in generally good health (ECOG 0-1).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06958419Recruiting· Phase 2/Phase 3
Short radiation plus targeted drugs for advanced colon cancer

This trial tests a combination of short-course radiation, chemotherapy, targeted therapy (bevacizumab), and an immunotherapy drug (PD-1 inhibitor) for people with advanced colorectal cancer that has spread and is not curable with surgery. It aims to see if this approach can help shrink tumors and improve outcomes.

Guangzhou, Guangdong
NCT06764680Recruiting· Phase 2
Oral drugs and radiation for advanced colorectal cancer after standard therapy

This trial tests a combination of oral chemotherapy, targeted therapy, and immunotherapy, with or without radiation, for people with advanced colorectal cancer that hasn't responded to at least two prior treatments. The goal is to see if this approach can help shrink tumors or slow the disease.

Guangzhou, Guangdong
NCT05747716Not yet recruiting· Phase 2
Targeted radiation plus immunotherapy for advanced colorectal cancer

This study tests a combination of precisely targeted radiation (SBRT) with two drugs: fruquintinib (a pill that blocks blood supply to tumors) and antibodies that boost your immune system to fight cancer (PD-1 and CTLA-4 inhibitors). It is for people with advanced colorectal cancer who have already tried two standard chemotherapy treatments.

Wuhan, Hubei
NCT06858969Not yet recruiting· Phase 2
Drug combination for advanced colorectal cancer

This study tests a new combination of drugs, including an immunotherapy and a targeted therapy, for colorectal cancer that has spread. The goal is to see if this combination can help shrink tumors or slow the cancer. It is designed for people who have not yet received treatment for metastatic disease.

NCT07116577Not yet recruiting· Phase 2
Radiation plus drug combination for advanced colorectal cancer

This trial tests a combination of radiation therapy with three drugs (an immunotherapy, a chemotherapy pill, and a targeted therapy) for advanced colorectal cancer. It aims to see if this combination can shrink tumors and improve outcomes for people whose cancer has not responded to standard treatments.

Jinan, Shandong
NCT07535632Not yet recruiting· Phase 2
Combination treatment for advanced colorectal cancer after two prior therapies

This trial combines a special type of radiation, immunotherapy, a targeted blood-vessel drug, and a chemotherapy pill for patients whose colorectal cancer has continued to grow after two prior treatments. The hope is that this combination can shrink tumors or slow down the cancer better than current options.

Shanghai, Shanghai Municipality

Hear when a new Immune Response trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.