Retifanlimab with or without DFMO for progressive high-grade gliomas
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This study tests a combination of two drugs—retifanlimab (an immunotherapy that helps your immune system fight cancer) and DFMO (a medicine that may stop tumor growth)—in people with high-grade brain tumors that are growing. Participants will receive these treatments before and after their planned surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older
- You have a type of high-grade brain tumor (like glioblastoma, astrocytoma, or oligodendroglioma) that is growing
- You are scheduled for surgery to remove the tumor as part of your regular care
- You can do most daily activities on your own
- Your blood counts and organ functions are within safe ranges based on recent tests
- You are not pregnant or nursing and are willing to use effective birth control if applicable
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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