Triple cholesterol medicine for heart disease prevention
Treatments studied
Part of Heart & circulation, Hormones & metabolism clinical trials.
This trial tests a triple combination of medications (bempedoic acid, ezetimibe, and a high-intensity statin) in people who have never had a heart attack or stroke but have moderate to severe coronary artery disease. The goal is to see if this combination lowers cholesterol and reduces future heart risks more effectively than standard care.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have never taken cholesterol-lowering medication (like statins)
- You have significant plaque buildup in your heart's arteries (coronary atherosclerosis) but no prior heart attacks, strokes, or procedures to open blocked arteries
- You are not expected to need a revascularization procedure (like stent or bypass) during the trial
- You do not have conditions like familial hypercholesterolemia, gout, severe kidney disease, or significant heart rhythm problems
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two new medicines—obicetrapib and bempedoic acid—to see which one better lowers cholesterol in people whose cholesterol remains high despite taking standard medications. If your cholesterol isn't controlled well enough with current drugs, this trial may help you access an experimental treatment.
This study observes patients with high cholesterol or mixed lipid disorders who are taking bempedoic acid, alone or with ezetimibe, to see how it works in real life. It aims to gather information that may help doctors better manage cholesterol.
This study compares two approaches to lowering 'bad' cholesterol (LDL-C) in people hospitalized with acute coronary syndrome (a heart attack or unstable angina). One approach uses two medications (a statin plus another pill), and the other uses three (adding an injectable medicine). The goal is to see if the triple therapy lowers cholesterol more effectively and helps prevent future heart problems.
This trial tests a combination pill of two cholesterol-lowering medicines (pitavastatin and ezetimibe) in adults who have been taking either atorvastatin or rosuvastatin for at least 3 months. It aims to see if switching to this new combination is safe and effective.
This study tests whether adding a medication called bempedoic acid to standard cholesterol-lowering pills is better at lowering cholesterol after a heart attack. If you have recently had a heart attack and are already on statins, this might be an option to help prevent future heart problems.
This study tests whether adding an extra cholesterol-lowering drug (bempedoic acid) to the usual treatment soon after a heart attack or related event can lower 'bad' cholesterol more effectively. It may help reduce the risk of future heart problems.
Hear when a new Coronary Atherosclerosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.