Thalidomide for children with PFAPA fever
Treatments studied
Part of Ear, nose & throat, Genetic & congenital, Infections, Lungs & breathing, Mouth & dental, Skin clinical trials.
This trial tests whether the drug thalidomide can reduce fever episodes in children with PFAPA syndrome. It may help children who still get frequent fevers even though steroids work temporarily.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child must be between 3 and 18 years old.
- Your child must have a PFAPA diagnosis (per standard criteria).
- Your child must have had at least 3 fever episodes in the last 6 months.
- Fever episodes must have responded to steroids (temperature returning to normal within 24 hours).
- Your child must not have other periodic fever syndromes, immune problems, or cancer.
- Your child must not have previously taken immunosuppressive drugs, thalidomide, or colchicine.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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