Finding the right dose of protamine to reverse heparin after heart bypass
Part of Heart & circulation clinical trials.
This study is testing different doses of a medication called protamine, which is given after heart surgery to reverse the effects of heparin (a blood thinner). The goal is to find the safest and most effective dose for patients who have had a heart-lung bypass machine during surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older
- You are scheduled for planned (not emergency) heart surgery that uses a heart-lung bypass machine
- You will receive heparin (a blood thinner) during your surgery as part of the standard hospital routine
- You are able to give written consent before your surgery
- You must not have a known allergy to protamine (the reversal drug)
- You must not have a bleeding disorder or take blood thinners that cannot be safely stopped before surgery
- You must not have severe kidney or liver problems
- You must not be pregnant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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