Weight loss drug for obesity with sleep apnea
Treatments studied
Part of Brain & nervous system, Lungs & breathing clinical trials.
This trial is testing an investigational medication (GZR18) to help people with obesity and obstructive sleep apnea (a condition where breathing stops during sleep) lose weight. It is given alongside the usual positive airway pressure (PAP) therapy, which helps keep the airway open during sleep. The goal is to see if the drug can improve weight and possibly sleep apnea symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- Your body mass index (BMI) is 28 or higher (a measure of body size).
- You have tried to lose weight through diet before but were not successful.
- You have been diagnosed with obstructive sleep apnea (OSA) and have a sleep test that shows moderate or severe apnea (AHI of 15 or more events per hour).
- You have been using a positive airway pressure (PAP) machine to treat your sleep apnea for at least 12 weeks before starting the trial, and you plan to keep using it during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new once-a-week injection (called GZR18) to help people with obesity and sleep apnea lose weight and improve their breathing during sleep, without using a CPAP machine. The treatment may help you lose weight and reduce sleep apnea symptoms.
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This trial tests an injection called HRS9531 to see if it helps people with obstructive sleep apnea (OSA) and obesity who already use a CPAP or similar breathing device. It may help by reducing weight and improving breathing during sleep.
This study tests an investigational medicine (HDM1005) for people who have both obesity and obstructive sleep apnea (where breathing stops during sleep) and who already use a CPAP machine. The goal is to see if the medicine can reduce breathing pauses and improve sleep quality compared to a placebo.
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