Clin2
NCT07542288Possibly a fitNot yet recruiting

Comparing steroids for brain swelling during radiation therapy

Brain Metastases From Solid Tumors

Treatments studied

Part of Brain & nervous system, Cancer clinical trials.

This trial compares two common steroid medications (methylprednisolone and dexamethasone) to see which one reduces swelling around brain tumors better during radiation therapy. If you have brain metastases and are planning radiation, this study might help find the best way to control symptoms like headaches or weakness.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2/Phase 3
Enrollment
400 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You must be between 18 and 75 years old.
  • You need at least one brain metastasis with swelling (edema) that is causing symptoms.
  • You must be scheduled for whole-brain radiation or stereotactic radiosurgery.
  • Your doctor expects you to live at least 3 more months.
  • You must be able to complete surveys and sign a consent form.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06888817Recruiting· Phase 3
Bevacizumab vs steroids for brain radiation injury

This trial tests if bevacizumab works better than steroids for people with brain swelling caused by radiation. If you have this condition and meet certain health requirements, you may join.

Amsterdam
NCT07044557Recruiting
Avoiding dexamethasone in brain metastasis surgery

This trial tests whether skipping the steroid dexamethasone around brain tumor surgery is safe and effective for patients with brain metastases. If you have a new brain tumor and a mass elsewhere in your body, you may be able to join.

Louisville, Kentucky
NCT06132685Recruiting· Phase 2
Dexamethasone dosing after brain tumor surgery

This trial tests how to best use dexamethasone (a steroid) after brain tumor surgery to help recovery and reduce swelling. It looks at different dosing schedules for patients with common brain tumors.

Atlanta, Georgia
NCT03184038Recruiting
Testing brain function in people with brain metastases after radiosurgery

This study looks at how well your thinking and memory work after treatment with radiosurgery for brain metastases. It may help researchers understand which patients benefit best and how to monitor side effects on brain function.

Sewell, New Jersey
NCT05222620Recruiting· Phase 2
SRS methods for untreated brain metastases under 4 cm

This trial compares two stereotactic radiation strategies for patients who have intact (not previously radiated) brain metastases that are limited in size. It aims to see which approach works best in controlling the cancer while reducing side effects.

Scottsdale, Arizona
NCT06649058Recruiting· Phase 2
Study on combining drugs and radiation for brain metastases

This trial is for people with cancer that has spread to the brain (brain metastases). It tests a new approach where you start a systemic therapy (drugs that travel through your body) and later add focused radiation to the brain tumors, instead of treating them right away. The goal is to see if this sequence works well and avoids unnecessary side effects.

Houston, Texas

Hear when a new Brain Metastases From Solid Tumors trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.