Enarodustat plus CsA for newly diagnosed low-severity aplastic anemia
Treatments studied
Part of Blood & lymphatic clinical trials.
This trial tests a new drug called enarodustat combined with an existing immune-suppressing medicine (CsA) to treat aplastic anemia—a rare blood disorder where your bone marrow doesn't make enough blood cells. The goal is to help your body produce more red blood cells without needing a bone marrow transplant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old
- You have been diagnosed with transfusion-dependent non-severe aplastic anemia (low-severity form where you need blood transfusions)
- Your hemoglobin (red blood cell protein) is below 90 g/L
- You have not had a bone marrow transplant and are not a suitable candidate for one right now
- Your liver and kidney function tests are less than twice the upper normal limit
- You have an ECOG score of 2 or better (a measure of how well you can do daily activities)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of four medicines (cyclosporine, eltrombopag or hetrombopag, romiplostim, and supportive care) for newly diagnosed aplastic anemia—a serious blood disorder where the bone marrow stops making enough blood cells. The goal is to help your bone marrow work better and reduce your need for blood transfusions.
This trial tests if a drug called luspatercept can help people with a type of aplastic anemia that requires regular blood transfusions. It may reduce how often you need transfusions by boosting your body's own blood cell production.
This study tests a daily pill that helps people with chronic kidney disease and anemia make more red blood cells, which may reduce the need for other anemia treatments. It is for patients who are not on dialysis and do not plan to start dialysis or have a kidney transplant within the next six months.
This trial tests enarodustat, a pill for anemia, in people with chronic kidney disease who are not on dialysis. It aims to see if it can safely raise hemoglobin levels.
This trial tests whether starting enarodustat (a pill) at different doses can raise red blood cell levels and treat anemia in people with moderate-to-severe chronic kidney disease who are not yet on dialysis.
This trial tests if sirolimus (an immune-suppressing drug) works better than current treatments for aplastic anemia patients who did not improve or had side effects from cyclosporin. It aims to find a new option to help your body make more blood cells.
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