Brain Stimulation for Depression in Multiple Sclerosis
Part of Brain & nervous system, Immune system & allergy clinical trials.
This study tests whether transcranial magnetic stimulation (TMS)—a non-invasive procedure that uses magnetic pulses to stimulate the brain—can help treat depression in people with multiple sclerosis who haven't benefited enough from antidepressants or therapy. The goal is to see if TMS is safe and effective for this specific group.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18–65 years old
- Diagnosed with relapsing-remitting or primary-progressive multiple sclerosis
- Moderate to severe depression (not adequately helped by at least one antidepressant or therapy course)
- Stable on MS and depression medications for at least 3–4 weeks
- No metal implants in the head (except small titanium plates or dental fillings), pacemakers, or other devices that could interfere with brain stimulation
- No active suicidal thoughts or recent substance/alcohol abuse (within 3 months)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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