CAR T-cell therapy for hard-to-treat B-cell leukemia
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests a new type of CAR T-cell therapy—a treatment that uses your own immune cells engineered to fight leukemia cells. It is designed for patients with B-cell acute lymphoblastic leukemia (ALL) that has come back or stopped responding to standard treatments, and whose leukemia cells have a specific marker called TSLPR.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have been diagnosed with B-cell acute lymphoblastic leukemia (ALL) that has returned or stopped responding after at least two rounds of treatment
- Your leukemia cells must express a protein marker called TSLPR (at least 80% of cancer cells must have it)
- You must be age 18 or older and able to perform light activities (Karnofsky score of 50 or higher)
- Your heart, lungs, liver, and kidneys must be functioning well enough to tolerate treatment
- You must have measurable disease visible on tests (evidence of minimal residual disease or PET-avid disease)
- You cannot be pregnant, and must use birth control during and for several months after treatment
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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