Aspirin versus clopidogrel for heart disease in Gulf countries
Treatments studied
Part of Heart & circulation clinical trials.
This study compares two blood-thinning medicines, aspirin and clopidogrel, to see which is better at preventing future heart problems in people with chronic coronary artery disease. If you have had a heart attack or unstable angina at least 6 months ago, this trial may help you understand an additional option for your heart health.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have significant coronary artery disease, confirmed by a heart artery X-ray (angiogram) showing a blockage of 50% or more in the main artery or 70% or more in other arteries, or by a special pressure test (FFR or iFR) showing reduced blood flow.
- You must have had a heart attack or unstable angina at least 6 months ago, regardless of any treatments you received (like stents, bypass surgery, or medication only).
- You must be willing to take either aspirin or clopidogrel, and you must agree to participate by signing a consent form.
- You cannot be pregnant, breastfeeding, or planning a pregnancy during the study.
- You cannot be taking certain medications like blood thinners (warfarin, DOACs, heparin), specific antidepressants (fluoxetine), or high doses of methotrexate, lithium, or probenecid.
- You must be able to attend follow-up visits for up to 5 years and be able to afford clopidogrel if it is not covered by your health system.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two different daily doses of aspirin (50 mg vs 100 mg) when taken with a standard blood thinner (P2Y12 inhibitor) after getting a heart stent. It aims to see if a lower aspirin dose works just as well with fewer side effects.
This trial compares two common “blood thinner” combinations to prevent problems after a PCI procedure for complex blocked heart arteries. It may help your care team find which combination works better for people with higher-risk artery patterns.
This trial tests whether clopidogrel (a blood-thinning medicine) can prevent future heart attacks or strokes in people who have early, “subclinical” plaque in their heart arteries. You may be considered if scans show plaque but not major artery blockage that needs a procedure.
This trial tests whether daily aspirin is safe and effective for people who have stable (chronic) coronary artery disease but cannot have procedures to open blocked arteries. It may help reduce future heart problems, while also checking for side effects and risks from aspirin.
This study compares two ways to lower the chances of another heart attack: taking the standard medicine (clopidogrel) versus taking a combination of aspirin and a lower dose of a blood thinner (rivaroxaban). If you join, you'll be assigned to one of these options to see which works better for people like you.
This trial tests whether taking just one blood thinner (clopidogrel) is as safe and effective as taking two (clopidogrel plus aspirin) for older adults or people at high bleeding risk who have had a drug-coated balloon procedure to open blocked heart arteries.
Hear when a new Chronic Coronary Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.