Brain Protection During Surgery for Older Adults
Part of Brain & nervous system, Mental health clinical trials.
This trial tests whether two medications (dexmedetomidine and esketamine) plus a non-invasive brain stimulation treatment can help prevent thinking and memory problems that sometimes happen after surgery in people over 65. You would receive these treatments during and after your surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 65 and 90 years old
- You have mild to moderate cognitive impairment (shown by a memory screening test score below 27)
- You are having planned surgery (not heart or brain surgery) lasting more than 1 hour under general anesthesia
- You will use a pain pump (patient-controlled IV pain medication) after surgery
- You do not have serious heart problems, uncontrolled thyroid problems, or severe liver/kidney disease
- You have no metal implants in your head or neck (like cochlear implants or pacemakers)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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