Clin2
NCT07582887Likely a fitRecruiting

Genetic Testing to Predict Side Effects from Breast Cancer Antibody Drugs

Breast CancerMetastatic Breast CancerDrug-Related Side Effects and Adverse ReactionsPharmacogenetic Variant

Treatments studied

Part of Cancer, Skin clinical trials.

This study examines how genetic differences affect how your body handles three newer breast cancer medications (Sacituzumab Govitecan, Trastuzumab Deruxtecan, or Datopotamab Deruxtecan). A blood test will check your UGT1A1 gene to help doctors predict which side effects you might experience and adjust your treatment accordingly.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
70 people
Ages
18 years and older
Study type
Observational

Who can take part

  • You are 18 years old or older
  • You have been diagnosed with locally advanced or metastatic breast cancer (cancer that has spread)
  • You are starting or currently receiving one of three specific antibody-drug conjugate medications
  • You are willing to provide a blood sample for genetic testing
  • You sign a consent form agreeing to participate in the genetic study

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06665178Recruiting· Phase 2
Testing SG after T-DXd in ER+/HER2-low metastatic breast cancer

This trial tests whether a different chemotherapy drug, called sacituzumab govitecan (SG), can help people with ER+/HER2-low metastatic breast cancer who have already been treated with trastuzumab deruxtecan (T-DXd). It also looks at genetic markers in your tumor to predict who might benefit from SG.

Vancouver, British Columbia
NCT06240195Recruiting
Study of sacituzumab govitecan for advanced triple-negative breast cancer

This study is testing a drug called sacituzumab govitecan (SG) for people with advanced triple-negative breast cancer who have already had other treatments. The goal is to see how well the drug works and what side effects it causes, using your tumor samples to look for clues (biomarkers).

Rome, Rome
NCT07067138Recruiting
Genetic testing to guide treatment for advanced breast cancer

This study looks at the genes in your cancer to find a treatment that might work better for you. It tests your tumor sample to match you with a drug that targets your cancer's specific weaknesses.

Bethesda, Maryland
NCT05693766Recruiting· Phase 2
Gene test guides treatment for hormone-positive breast cancer

This trial studies whether a gene-signature test can help guide treatment choices for people with hormone receptor–positive (ER and/or PR) breast cancer that has spread or can’t be fully removed. It may help find the best therapy approach after prior hormone therapy and targeted cancer medicine.

Birmingham, Alabama
NCT06263543Recruiting· Phase 2
Sequencing antibody-drug conjugates in ER+, HER2-low breast cancer

This trial tests different sequences of antibody-drug conjugates (a type of targeted chemotherapy) for people with ER-positive, HER2-low or ultra-low metastatic breast cancer that has stopped responding to hormone therapy and has progressed on Enhertu. You must have had 1–4 prior chemotherapies for metastatic disease.

Miami, Florida
NCT04638725Recruiting
Genetics study to find why HER2 breast cancer treatment varies

This study looks at genetic factors to understand why some people’s HER2-positive breast cancer responds better—or has more side effects—after treatment. Your info and possible past treatment history may help researchers improve how HER2 treatment is chosen and managed.

Strasbourg

Hear when a new Breast cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.