Exparel for pain after knee replacement
Part of Bones, joints & muscles, Pain clinical trials.
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years old or older.
- You are having your first total knee replacement on one knee (not both at once).
- The surgery is for arthritis (not for a previous knee replacement or other problem).
- You will be awake but numb from the waist down (spinal anesthesia) for the surgery.
- You have not been using strong daily pain medicines (opioids) or marijuana/cannabis in the past month.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
This study compares two different nerve-blocking anesthesia techniques to see which one controls pain better after knee replacement surgery. Both methods are designed to numb the area around your knee so you need less pain medication afterward.
This trial tests two types of numbing injections (nerve blocks) around the knee to help manage pain after total knee replacement surgery. The goal is to see if these injections reduce pain and improve recovery compared to standard pain treatment.
This study compares three different pain medicines given during total knee replacement surgery to see which one helps with recovery the best. It tracks your knee function using a smart implant.
This Phase 2 study compares two ways to reduce pain after total knee replacement (TKA): a steroid-enhanced nerve block versus a numbing shot called Exparel. It aims to see which option improves comfort and recovery after surgery done with spinal anesthesia.
This trial is testing a long-acting numbing medicine called Exparel to see how well it controls pain after a specific knee surgery (MPFL reconstruction) in teens and young adults. It may help reduce the need for strong painkillers after the operation.
Hear when a new Total Knee Arthroplasty trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.