Tested stronger pain-blocking shot for knee replacement surgery
Part of Bones, joints & muscles, Pain clinical trials.
This Phase 2 study compares two ways to reduce pain after total knee replacement (TKA): a steroid-enhanced nerve block versus a numbing shot called Exparel. It aims to see which option improves comfort and recovery after surgery done with spinal anesthesia.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are scheduled for a first-time, elective, bilateral total knee replacement (both knees), for osteoarthritis
- Your anesthesia plan is spinal anesthesia using plain 0.5% bupivacaine
- You are able to give consent and complete follow-up questionnaires by phone or online (or by email)
- You have no reason you can’t use the study medicines (acetaminophen, Celebrex, bupivacaine, DEX, MPA, or LB)
- You do not have bleeding problems, immune system problems, or a current/nearby infection at the nerve block site or in your body
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.
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This trial tests two different drugs (dexamethasone and dexmedetomidine) added to a standard nerve block for knee replacement. It aims to see which one provides better pain control after surgery.
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
This study compares two ways to manage pain after knee replacement surgery: one uses a long-lasting numbing medicine (liposomal bupivacaine), the other uses extra medicines alongside the numbing block. The goal is to find which approach gives better pain relief and helps you recover more comfortably.
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