Brain stimulation with an added medication for depression
Treatments studied
Part of Mental health clinical trials.
This study tests whether adding an experimental medication to a newer type of TMS brain stimulation can improve depression symptoms. It aims to find a new treatment option for people who haven't fully responded to standard care.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be able to safely receive TMS, a non-invasive magnetic brain stimulation treatment.
- Your antidepressant medications must be at a stable dose for at least the past month and stay stable during the trial.
- You cannot currently be receiving TMS, electroconvulsive therapy (ECT), or ketamine treatments.
- You must not have a history of seizures, epilepsy, or serious head injury (with loss of consciousness over 15 minutes).
- You must not have major brain conditions like recent stroke or tumor, or severe migraines that could interfere.
- You must not be pregnant and must be willing to have an MRI.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This early-stage study tests a type of magnetic brain stimulation called theta burst stimulation combined with study medications to help treat moderate to severe depression. Researchers want to understand how this combination affects brain communication and may help reduce depressive symptoms.
This study is testing whether a new type of brain stimulation called intermittent theta burst stimulation (iTBS) can help people with treatment-resistant depression (depression that hasn't improved with standard medicines). It also looks at certain blood markers to see if they can predict how well someone will respond to this treatment.
This study uses a special type of brain stimulation (rTMS, which uses magnetic pulses) to treat depression. It focuses on part of the brain called the orbitofrontal cortex and aims to understand how stimulating it helps improve mood.
This study tests a type of brain stimulation called cTBS (continuous theta burst stimulation) applied to a specific part of the brain (the precuneus) to see if it helps with treatment-resistant depression. It aims to provide a new option for people who haven't found relief from standard treatments.
This study tests a type of brain stimulation (guided iTBS) to improve depression when standard antidepressant treatments haven’t helped. It also checks that the treatment is safe for people who can meet the study and scan safety requirements.
This study tests how a specific kind of brain stimulation (repetitive transcranial magnetic stimulation) works for people with depression that has not responded to standard treatments. If you qualify, it may help doctors understand the mechanism and improve options for treatment-resistant depression.
Hear when a new Major Depression trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.