Comparing two acid reducers to prevent ulcers after variceal treatment
Treatments studied
Part of Digestive system clinical trials.
This study compares two medications, rabeprazole and vonoprazan, to see which one works better at preventing ulcers that can form after a procedure to treat varices (enlarged veins) in the esophagus. If you have cirrhosis and varices, this trial may help reduce pain and bleeding after your treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years old or older.
- You must have cirrhosis and enlarged veins in your swallowing tube (esophagus), confirmed by an endoscopy.
- You must not have liver cancer (hepatocellular carcinoma).
- You must not be currently taking acid reducers (like omeprazole) or vonoprazan for any other reason.
- You must not be taking blood thinners (anticoagulants or antiplatelets).
- You must be willing to participate in the study and give your consent.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether vonoprazan can reduce ulcers caused by a procedure that ties off enlarged veins in the esophagus (variceal band ligation). It is meant for people with liver cirrhosis who are scheduled to receive this treatment.
This study compares two treatments that reduce stomach acid after a bleeding ulcer has been repaired with an endoscope. It aims to find which one is better at preventing the ulcer from bleeding again.
This trial compares two medicines—vonoprazan and esomeprazole—to see which is better at healing acid damage to the esophagus (erosive esophagitis). If you have had heartburn and an endoscopy confirmed inflammation, you may be eligible for this study.
This study compares two acid-reducing medications, keverprazan and pantoprazole, to see which is better at stopping bleeding from the upper digestive tract (stomach or food pipe). If you have had bleeding in your stomach or intestines, this trial could help determine the most effective treatment for you.
This trial tests vonaprazan (two doses) against esomeprazole to see which better heals moderate-to-severe reflux esophagitis (a damaged esophagus from acid reflux) in 8 weeks. You may qualify if you have had heartburn or regurgitation for at least a month and your doctor found grade B, C, or D damage on an endoscopy.
This trial compares two medicines that reduce stomach acid to help heal ulcers that form after a procedure called ESD, which removes abnormal stomach tissue. The goal is to see if one medicine works better and has fewer side effects.
Hear when a new Endoscopic Variceal Band Ligation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.