Antibiotics in the bone for amputees with infection concerns
Part of Infections clinical trials.
This study tests giving antibiotics directly into the bone where a prosthetic limb is attached, to see if it helps treat or prevent infections at the surgical site. It is for adults who have had an amputation and are now concerned about an infection where the implant meets the bone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have had an amputation of the thigh, lower leg, or upper arm and have received an osseointegration implant (a metal post that connects the implant to the prosthesis).
- You are 18 years or older.
- You are able to return to the study site for follow-up visits for at least 1 year.
- You speak English or Spanish.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether putting antibiotics directly inside the bone during surgery can improve outcomes for an infected knee prosthesis when the implant is being kept. It may help more people avoid needing full implant removal and replacement.
This Phase 3 trial tests whether giving antibiotics by mouth (PO) works as well as giving antibiotics through a vein (IV) for an infected fracture that has not healed after prior surgery. It may help you understand which approach is safer and more effective for getting the bone to heal.
This trial tests whether adding antibiotics to the bone graft used during hip replacement surgery can lower the risk of infection. It may help people who need a bone graft as part of their hip replacement.
This trial tests a new way of giving antibiotics to people with severe open fractures in the leg, ankle, or foot. The goal is to see if it helps prevent infections after surgery.
This study tests a bone-anchored implant (directly attached to the thighbone) for people with a single leg amputation above the knee. It aims to see if this implant helps with pain, movement, and skin issues caused by a traditional socket prosthetic.
This study compares two antibiotic plans for acute (early) infections around an artificial knee or hip, using a procedure to clean the joint and try to keep the implant. It may help find the best approach to control infection and then prevent it from coming back with longer-term antibiotic treatment.
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