How a single dose of ketamine affects brain activity in people with depression
Treatments studied
Part of Brain & nervous system clinical trials.
This study looks at how a single low dose of ketamine (a medication that can lift mood) affects brain electrical activity in people who are already having brain electrodes placed for epilepsy monitoring. If you have mild depression symptoms, you might benefit from this research.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be staying in the epilepsy monitoring unit at Emory University for a clinically needed test called sEEG (electrodes placed in the brain to find where seizures start).
- You need to have at least mild depression symptoms at the start, measured by a short questionnaire.
- You must be able to understand English and complete simple bedside tasks or questionnaires.
- You will receive one dose of a low-dose ketamine (a safe anesthetic also used for depression) and be monitored for about 24 hours.
- You cannot have current thoughts of harming yourself with a plan or intent, or have a history of bipolar disorder or psychosis (like schizophrenia).
- There must be no medical reason that would make taking ketamine unsafe for you, such as uncontrolled high blood pressure or pregnancy.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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