How ketamine affects mood in people with epilepsy
Treatments studied
Part of Brain & nervous system clinical trials.
This study gives a single low-dose ketamine infusion to people who are already staying in the hospital for epilepsy monitoring, to see if it can quickly improve mild depression symptoms. Researchers will measure brain activity to understand why ketamine helps mood.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are staying at Emory's epilepsy monitoring unit for seizure recording with electrodes placed deep in your brain (sEEG).
- You have at least mild depression symptoms, such as a MADRS score of 7 or higher or a BDI-II score of 14 or higher.
- Your electrode placement includes areas on the midline of the brain, which is needed for the study measurements.
- You can understand English, complete questionnaires and tasks at the bedside, and give informed consent.
- You will remain in the hospital for about 24 hours after the ketamine infusion, unless your medical needs change.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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