Semaglutide for metabolic health in duchenne muscular dystrophy
Treatments studied
Part of Bones, joints & muscles, Brain & nervous system, Genetic & congenital, Hormones & metabolism clinical trials.
This study tests whether a medication called semaglutide (often used for weight management and diabetes) can improve metabolic health in people with Duchenne muscular dystrophy who are overweight. If you join, you may receive the drug or a placebo, and you'll have health checks including MRIs.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be male and at least 18 years old.
- Have a confirmed diagnosis of Duchenne muscular dystrophy (DMD) through genetic testing or muscle biopsy.
- Have a body mass index (BMI) of 30 or higher, OR a BMI of 27 or higher along with at least one weight-related health issue like high blood pressure, type 2 diabetes, or high cholesterol.
- Not have type 1 diabetes, poorly controlled type 2 diabetes (HbA1c > 8%), or use insulin or sulfonylureas for diabetes.
- No history of pancreatitis, medullary thyroid cancer, or a certain genetic syndrome (MEN2), and no allergies to the study drug semaglutide.
- Be willing to undergo MRI scans; some research parts require full-body or cardiac MRI, but if you can't tolerate that, you may still be able to participate in a limited way.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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