Clin2
NCT07760948Possibly a fitNot yet recruiting

HMB and vitamin D to protect muscle during semaglutide

Type 2 Diabetes Mellitus (T2DM)SarcopeniaObesityMuscle LossOlder Adults

Part of Brain & nervous system, Hormones & metabolism clinical trials.

This study tests whether taking HMB (a supplement) and vitamin D helps older adults keep their muscle while using semaglutide for weight loss. If you are starting semaglutide, this might help prevent muscle loss.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
90 people
Ages
65 years to 85 years
Study type
Interventional

Who can take part

  • You are between 65 and 85 years old.
  • You have type 2 diabetes (HbA1c at least 6.5% or you take diabetes medication).
  • Your body mass index (BMI) is 27 or higher.
  • You are just starting semaglutide (like Ozempic or Wegovy) as part of your normal care.
  • You can walk 400 meters (about 4 city blocks) with or without a cane.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07411378Not yet recruiting· Phase 2
Study of a plant extract with semaglutide for weight loss

This trial tests whether adding a plant-based supplement (called 20E) to the weight-loss medication semaglutide can improve weight loss and muscle health. You would take the supplement as capsules alongside your regular semaglutide treatment.

NCT06885736Recruiting
Preserving muscle with exercise and protein on weight loss drugs

This trial tests whether adding resistance exercise and extra protein can help you keep your muscle while taking weight loss medications like semaglutide or tirzepatide. It is for people with a BMI of 27 or higher who are not already exercising regularly.

Kuwait City
NCT05419726Recruiting
Semaglutide study to see how brown fat responds in weight loss

This trial studies how brown fat (a type of body fat) changes after starting semaglutide for weight loss. You may help researchers understand how this medication affects the body’s energy use, which could improve weight-loss treatments.

Los Angeles, California
NCT07101939Recruiting· Phase 2
Studying a medicine to preserve muscle during weight loss

This trial tests a new medicine, (S)-pindolol benzoate, given along with semaglutide (Ozempic/Wegovy). The goal is to see if it helps people lose mostly fat instead of muscle while on a weight loss program.

Belgrade
NCT07513168Recruiting· Phase 4
Low-dose semaglutide for weight loss in obese adults

This study tests whether a low dose of semaglutide (a once-weekly injection) can help obese adults without diabetes lose weight. Semaglutide works by reducing appetite and helping your body use food differently.

Hyderābād, Sindh
NCT05340868Recruiting
Study body response to oral semaglutide in overweight adults

This study looks at how genetics may affect your body’s early response to oral semaglutide, a weight-related diabetes medicine. You may be considered if you are overweight (or overweight with prediabetes) and can safely take part in the research.

Bialystok, Podlaskie Voivodeship

Hear when a new Sarcopenia trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.