Immunotherapy and chemotherapy before surgery for sinus cancer
Treatments studied
Part of Cancer, Ear, nose & throat, Lungs & breathing clinical trials.
This trial tests a combination of an immunotherapy drug (toripalimab) plus chemotherapy before surgery for sinus cancer that has not spread. The goal is to see if this treatment shrinks the tumor so surgery can be more effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a type of sinus cancer called squamous cell carcinoma or sinonasal undifferentiated carcinoma (both are common types).
- The cancer must be in the sinus area and not have spread to other parts of the body (no distant metastases).
- You must be able to have surgery to remove the tumor.
- You must be 18 years or older.
- You must be in good overall health (able to do daily activities without help).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of an immunotherapy drug (toripalimab) and two chemotherapy drugs (cisplatin and docetaxel) as a first treatment before surgery or radiation for advanced head and neck cancers. It may help shrink tumors that can't be easily treated with standard therapy.
This trial tests a combination of chemotherapy and an immunotherapy drug called Toripalimab before surgery for certain head and neck cancers. The goal is to see if this approach can reduce the extent of treatment needed while still being effective.
This Phase 2 study tests a treatment plan that combines immunotherapy with chemotherapy and chemoradiation for advanced squamous cell cancer in the nasal cavity or sinuses. It aims to improve cancer control in people who are newly diagnosed and have not had prior treatment for this cancer.
This trial tests pembrolizumab (an immune therapy) for locally advanced sinonasal cancer that can still be cured with local treatments. It aims to improve outcomes by helping your immune system better fight the tumor.
This trial tests whether combining chemotherapy with two immunotherapy drugs (PD-1 inhibitors) before surgery can improve outcomes for patients with advanced sinonasal carcinoma. It aims to shrink the tumor before removal.
This trial tests whether adding the immunotherapy drug cemiplimab to standard chemotherapy before surgery helps treat sinonasal squamous cell carcinoma. The goal is to see if this combination reduces tumors more effectively than chemotherapy alone.
Hear when a new Squamous Cell Carcinoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.