Fenfluramine and Depression: Testing a Serotonin Theory
Part of Mental health clinical trials.
This study tests whether a medication called fenfluramine can help researchers understand depression by measuring brain activity. Participants with moderate-to-severe depression or healthy volunteers will undergo brain scans while receiving this medication to help scientists learn more about how serotonin (a brain chemical) relates to depression.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 21 years or older
- Able to lie still on your back during brain scans without claustrophobia
- For depression participants: have moderate-to-severe depression, never taken antidepressants or off them for 8+ weeks, and see a regular doctor
- Able to use contraception (if applicable) and access the internet on your own device
- Not pregnant, breastfeeding, or using illicit drugs in the past 3 months
- No recent brain scans with radiation, no pacemakers or metal implants, and able to have blood drawn from an artery
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at whether fluoxetine, a common medication for mood, affects how young adults (18-24) experience emotions. It aims to understand emotional processing in healthy individuals without psychiatric history.
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
This study tests whether a targeted medication can improve mood and brain function in adults with major depression. If you qualify, you'll receive a study drug and have fMRI brain scans to see how your brain responds.
This trial tests whether flumazenil (a medication that reverses sedation from anti-anxiety drugs) can safely help patients wake up faster after electroconvulsive therapy (ECT), a treatment for severe depression. The goal is to see if it improves recovery time without causing problems.
This study uses a powerful 7T MRI scanner to look at a part of the brain called the amygdala, and tests how the drug citalopram affects brain activity during emotional tasks. It may help researchers understand more about mood disorders.
This trial tests whether fluoxetine (a common antidepressant) affects how young adults understand and experience social situations. You may participate if you are healthy, aged 18–24, and live in the UK.
Hear when a new Depression - Major Depressive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.