Testing the serotonin theory of depression with fenfluramine
Part of Mental health clinical trials.
This study uses a drug called fenfluramine to understand how serotonin, a brain chemical, is involved in depression. It compares people with moderate-to-severe depression who are not currently taking antidepressants to healthy volunteers.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 21 years or older.
- You must be able to lie on your back for brain scans (MRI and PET).
- You must be able to read and understand English and have internet access.
- If you have depression, you must score above 20 on a depression scale, have not taken antidepressants for at least 8 weeks, and are not considered treatment-resistant.
- If you are a healthy volunteer, you must not have any current or past psychiatric diagnosis.
- You must not be pregnant, breastfeeding, or planning to become pregnant, and must use reliable birth control.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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