Combination treatment for newborn brain injury
Treatments studied
Part of Brain & nervous system clinical trials.
This trial tests whether giving both magnesium sulfate and melatonin to newborns with brain injury from lack of oxygen works better than magnesium sulfate alone. The goal is to see if the combination improves recovery and reduces long-term disability.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Baby must be born at full term (37 weeks or later)
- Baby must have a low Apgar score (below 5) at 1 minute after birth
- Tests must show the baby's blood was too acidic (low pH or high base deficit)
- Baby must have at least moderate HIE, a form of brain injury due to lack of oxygen
- Baby must not have birth defects, growth problems, infections, heart disease, or inherited metabolic disorders
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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