Sildenafil plus cooling for newborn brain injury
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This study tests whether adding a medication called sildenafil (commonly used for blood pressure) to standard cooling treatment can improve brain recovery in newborn babies with brain injury from lack of oxygen. It aims to see if the combination is safe and effective in helping these babies develop better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Baby must be born at 36 weeks of pregnancy or later (full-term or close to it).
- Baby must be receiving cooling treatment (therapeutic hypothermia) for brain injury due to lack of oxygen around birth.
- Baby must have social security coverage (in France).
- At least one parent or legal guardian must give permission (informed consent).
- Baby must not have major birth defects or chromosomal abnormalities.
- Baby must not be in another research study or receiving certain other medications (like nitrates or other erectile dysfunction drugs).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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