Metformin for depression with obesity: a genetic study
Treatments studied
Part of Hormones & metabolism, Mental health clinical trials.
This trial tests if adding metformin to antidepressants helps people who have both depression and obesity. It also looks at genetic factors that might affect treatment response.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have been diagnosed with recurrent depression (at least two episodes)
- You are overweight or obese (BMI of 23 or higher, using the Asian cutoff)
- You are either not taking antidepressants, or have been off them for at least 2 weeks (or 7 days depending on the medication)
- You have moderate to severe depression symptoms (BDI score 13 or higher, or PHQ-9 score 4 or higher)
- You do not have diabetes, uncontrolled thyroid, heart or liver problems, or other serious medical conditions
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether adding metformin (a diabetes medicine) to usual antidepressant treatment can help improve depression in people who are overweight or obese. It is for adults age 18–44 who are newly diagnosed with depression and do not have diabetes.
This trial tests if metformin can help older adults (60-75) who are overweight and have mild memory problems. It aims to see if the drug can slow down or improve memory issues.
This trial tests whether dapagliflozin, a diabetes medication, can help treat major depression. It is for adults who have been depressed for at least 2 months and score high on a depression scale.
This trial tests whether metformin, a common diabetes medicine, can help people with obesity lose weight. It is for people who do not have diabetes and have not used weight loss treatments in the past year.
This study tests two investigational medications, MET233 and MET097, in people with obesity or overweight, with or without type 2 diabetes. It aims to see if the combination can help with weight loss and blood sugar control.
This trial tests whether metformin can help adults with intellectual disability who gained weight from long-term antipsychotic medicines. If you qualify, you may be assigned metformin to improve weight and related health measures.
Hear when a new Depression trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.