Metformin to reduce weight gain from antipsychotic medicines
Treatments studied
Part of Brain & nervous system, Hormones & metabolism, Mental health clinical trials.
This trial tests whether metformin can help adults with intellectual disability who gained weight from long-term antipsychotic medicines. If you qualify, you may be assigned metformin to improve weight and related health measures.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re an outpatient (not currently hospitalized) and generally stable
- You’re age 16 to 65 and have an intellectual disability diagnosis
- You’ve been taking an antipsychotic at a stable dose for at least 3 months
- Your weight is in a higher range (BMI 30+), or BMI 27+ with a related problem (like high blood pressure or sleep apnea), or BMI 25+ if you gained 5%+ weight after starting the antipsychotic
- You must have no major health issues that make metformin unsafe (for example serious heart/lung/kidney problems, certain acid build-ups, or major recent events)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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