Papaverine for small blood vessel function in septic shock
Treatments studied
Part of Infections clinical trials.
This study tests whether a blood vessel-relaxing medicine called papaverine can improve tiny blood flow in the mouth (a sign of overall circulation) in people with septic shock. If you are in the ICU with septic shock and on a ventilator, this trial may help doctors learn how to better support your recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 85 years old.
- You have septic shock (a severe infection causing very low blood pressure) that started within the last 24 hours.
- You are getting a steady IV medicine (norepinephrine) to keep your blood pressure up and are on a breathing machine.
- You do not have serious heart problems (like a recent heart attack or dangerous rhythm).
- You are not allergic to papaverine, and you are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a medicine called anisodamine can improve blood flow in tiny vessels (microcirculation) under your tongue and help stabilize blood pressure in patients with septic shock. It may offer a new way to support recovery in the ICU.
This study tests whether adding a sedative called dexmedetomidine, along with your current care, can improve blood flow in small blood vessels under the tongue for people with septic shock in the ICU.
This study tests whether a traditional Chinese medicine injection (Shenfu) can improve blood flow and organ function in patients with septic shock—a life-threatening infection where the body's blood pressure drops dangerously low despite fluids. Researchers want to see if this treatment helps the heart pump blood more effectively to vital organs.
This study tests a medication called esmolol to see if it helps blood flow in tiny blood vessels under the tongue for people with septic shock. If you have a fast heart rate despite treatment, this trial may help your doctors better manage your condition.
This trial studies how blood flow and organ “perfusion” look in ICU patients who are struggling with infection and low blood pressure. It may help doctors better measure and manage shock by comparing hemodynamic readings during standard treatment.
This trial tests whether adding vasopressin (a drug that helps raise blood pressure) to standard treatment can help people with septic shock. It is for adults who already need a high dose of another blood pressure medicine called noradrenaline.
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