Papaverine for blood flow in septic shock
Treatments studied
Part of Infections clinical trials.
This study tests whether a medication called papaverine can improve blood flow in the tiny vessels under the tongue in people with septic shock, which may help their organs get more oxygen. It is for patients in the intensive care unit (ICU) who are already on strong blood pressure support and a ventilator.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 18 and 85 years old.
- Have septic shock (a severe infection causing very low blood pressure) and be on IV medications to maintain blood pressure.
- Be enrolled within 24 hours of the shock diagnosis.
- Be on a breathing machine (ventilator).
- Have special monitoring in place (arterial line, central line, and a device to check blood flow under the tongue).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a medication called anisodamine to see if it can improve blood flow in tiny blood vessels under the tongue in people with septic shock. This might help their organs work better and make them recover faster.
This trial tests whether an herbal medicine called Shenfu Injection can improve blood flow regulation in patients with septic shock. It aims to help stabilize blood pressure and might reduce the need for vasopressors.
This study tests whether adding a sedative called dexmedetomidine affects blood flow in tiny vessels under the tongue and overall circulation in patients with septic shock. It may help doctors choose better sedation to improve recovery.
This trial studies how blood flow and organ “perfusion” look in ICU patients who are struggling with infection and low blood pressure. It may help doctors better measure and manage shock by comparing hemodynamic readings during standard treatment.
This trial tests whether adding vasopressin (a hormone that narrows blood vessels) to usual care can improve recovery in patients with septic shock (a severe infection causing very low blood pressure). If you are already on a strong blood pressure medication, this study may help stabilize your condition.
This trial tests if giving methylene blue early can improve blood flow in patients with sepsis who still have low blood pressure despite fluids and are on high doses of noradrenaline. It aims to help stabilize their condition.
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