Sedation drug effects on blood flow in septic shock
Treatments studied
Part of Blood & lymphatic, Genetic & congenital, Heart & circulation, Infections clinical trials.
This study tests whether adding a sedative called dexmedetomidine affects blood flow in tiny vessels under the tongue and overall circulation in patients with septic shock. It may help doctors choose better sedation to improve recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 85 years old.
- You have septic shock (severe infection causing low blood pressure) and need a medication to keep blood pressure up.
- You are in the intensive care unit (ICU) and on a breathing machine.
- You are already receiving sedative or pain medication, and the doctor plans to add dexmedetomidine.
- You have a special monitoring device (PiCCO) to check your heart and blood flow.
- You or your legal representative can give written permission to join.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a medication called anisodamine to see if it can improve blood flow in tiny blood vessels under the tongue in people with septic shock. This might help their organs work better and make them recover faster.
This trial tests an early use of a sedative medicine called dexmedetomidine in people with septic shock. It aims to calm the body's stress response, which might improve recovery.
This trial tests if dexmedetomidine, a sedative, can help protect the kidneys of critically ill patients with sepsis who develop acute kidney injury (a sudden drop in kidney function). It is for adults in the ICU who need a breathing tube or mask within 48 hours of kidney injury.
This study tests whether giving a medicine called dexmedetomidine (which helps people relax and sleep) as part of a sleep-promoting routine can reduce confusion and delirium in the intensive care unit (ICU). It may help you sleep better and recover more smoothly.
This trial tests whether combining two sedative medications, esketamine and dexmedetomidine, is safer and more effective than using dexmedetomidine alone for treating hyperactive delirium in ICU patients who need breathing support. If you or a loved one are experiencing severe confusion and agitation while on a breathing machine, this study may offer a new treatment option.
This study tests a medicine called dexmedetomidine, which may help calm the body's stress response during septic shock, possibly improving blood pressure and organ function. The trial is for patients in intensive care who are already on strong blood pressure support but are not improving.
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