Testing PL54 injection for adults with PKU
Part of Brain & nervous system, Genetic & congenital, Hormones & metabolism clinical trials.
This study tests a new injection called PL54 to see if it is safe and tolerable for adults with phenylketonuria (PKU), a condition where the body cannot break down an amino acid called phenylalanine. It is designed for people with high blood phenylalanine levels and may offer a new treatment option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 55 years old.
- You have been diagnosed with PKU and have high phenylalanine levels in your blood.
- You are able to keep your diet stable from 3 days before screening until the end of the study.
- You have not used any PKU medication or injectable medicines containing PEG in the past 2 to 3 weeks.
- You have not used Pegvaliase (PALYNZIQ®) or any gene therapy for PKU before.
- You do not have serious health conditions like heart, liver, or immune system problems, and you are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new injection called GS1168 for adults with phenylketonuria (PKU) whose current treatments are not working well. The goal is to see if it can help control their PKU better.
This study tests a new medicine called JNT-517 for people with phenylketonuria (PKU) over a long period. It aims to see if the drug can help manage PKU safely and effectively.
This study tests a new oral medication (MZE782) for adults with PKU. It looks at how safe and effective the drug is, and it requires you to keep your diet stable for the entire study.
This study tests a new microtablet form of protein substitute for people with PKU. It aims to see if taking these tablets helps you meet your protein needs while staying on your PKU diet.
This study looks at adults with phenylketonuria (PKU) using advanced testing (called multiomics) to understand how the condition affects the body. If you took part in a previous PKU study (ECOPHEN) and are willing to give a saliva sample for DNA analysis, this trial may be for you.
This study tests a new home blood test (Egoo Phe) for measuring phenylalanine levels in people with PKU, as well as in healthy adults. It aims to see if it is accurate and easy to use.
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