Lymphatic surgery plus donepezil for Alzheimer's disease
Part of Brain & nervous system clinical trials.
This study tests if a surgical treatment that improves brain waste drainage, combined with the standard Alzheimer's drug donepezil, works better than the drug alone. It is for people with mild-to-moderate Alzheimer's dementia.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 50 to 80 years
- Diagnosed with Alzheimer's disease dementia
- MMSE score 24 or less (mild to moderate cognitive decline)
- Positive amyloid PET scan
- HAMD score 17 or less (mild or no depression)
- Hachinski score 7 or less (no signs of vascular dementia)
- No Alzheimer's medication for the past month
- CDR-SB score 9.5–15.5 (moderate stage)
- No major heart, lung, liver, kidney, or bleeding issues
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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