Gene therapy injection for moderate to advanced Parkinson's disease with GBA1 mutation
Part of Brain & nervous system clinical trials.
This trial tests an experimental gene therapy injected directly into the brain, designed for people with Parkinson's disease who carry a specific genetic change called GBA1. The goal is to see if the treatment is safe, tolerable, and helps improve motor symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 30 and 70 years old.
- You have been diagnosed with Parkinson's disease for at least 3 years.
- You have a GBA1 gene mutation (a specific genetic change).
- Your Parkinson's symptoms are moderate to advanced, meaning they affect your ability to move and daily activities.
- You are currently taking stable Parkinson's medication (like levodopa) and still have motor fluctuations or periods when symptoms are not well controlled.
- You have not had prior brain surgery (like deep brain stimulation) or gene/cell therapy.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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