Pregnenolone for cannabis use and depression
Treatments studied
Part of Mental health clinical trials.
This study tests if a natural hormone called pregnenolone can help people who use cannabis frequently and also have depression. You would take pregnenolone pills and see if your cannabis use and mood improve.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 50 years old
- You have been diagnosed with cannabis use disorder and major depression
- You use cannabis at least 4 days a week
- You have a positive urine test for THC
- You are willing to try to cut back on cannabis
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if a natural steroid called pregnenolone can help people who have both alcohol use disorder and major depression. You would take the study medication for several weeks and have brain scans and mood assessments to see if it reduces drinking and improves mood.
This study tests a digital (online) program designed to help people who struggle with both depression and cannabis use. If you're feeling down and also using cannabis more than you'd like, this program might help you manage both.
This study tests if psilocybin (a substance that can change how you think and feel) can help people reduce or stop using cannabis. You will receive support and be monitored closely throughout the trial.
This early-phase study tests whether a CBD pill (compared with a placebo sugar pill) can affect cannabis use and stress in people ages 18–25 who use cannabis very frequently. It may help your stress levels and cannabis-related symptoms while researchers carefully monitor safety and abstinence periods during visits.
This trial tests if tirzepatide, a hormone-like medicine, can help people with severe cannabis use disorder reduce their cannabis use. It may work by changing how your body responds to certain signals.
This trial tests whether a treatment called repetitive transcranial magnetic stimulation (a non-surgical magnetic stimulation to the brain) can help people reduce or stop cannabis use. You may be eligible if you have cannabis use disorder and meet specific safety and symptom criteria.
Hear when a new Cannabis Use Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.