Clinical trials
Cannabis Use Disorder clinical trials
Below are recruiting cannabis use disorder clinical trials, each written for real people, not researchers. We’re tracking 155 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05486234Recruiting
Study to reduce cannabis and alcohol use with teen and caregiver
This study looks at ways to help teens cut down on cannabis and alcohol use. You may qualify if you’ve been using both in the last three months and your caregiver is able to join and consent.
Charleston, South CarolinaAges 13–17 - NCT06259916Recruiting
EEG to tell alcohol vs. cannabis intoxication
This study uses electroencephalography (EEG) to see if brain activity can tell whether you are drunk, high, or both. Results might help improve safety in the future.
Fort Collins, ColoradoAges 21–50 - NCT06085222Recruiting
App and computer study for stress in daily cannabis users
This study tests if a smartphone app and computer program can help regular cannabis users manage stress. It is for people who use cannabis daily or nearly daily and feel stressed.
Tallahassee, FloridaAges 18–30 - NCT06107062RecruitingPhase 2
CBD treatment for cannabis concentrate users
This trial tests CBD as a potential treatment for heavy cannabis concentrate users who want to cut down or quit. You would take CBD daily and attend regular visits to track your progress.
Boulder, ColoradoAges 21 years+ - NCT06124846Recruiting
Cannabis break and brain changes in teens
This study looks at what happens in the brain when teens with cannabis use disorder stop using cannabis for 6 weeks. It uses MRI scans to see changes in areas that control habits and decisions.
Minneapolis, MinnesotaAges 15–18 - NCT05453513Recruiting
Study how depression and cannabis affect the brain in young adults with HIV
This study looks at brain activity to understand how depression and cannabis use may be linked in young adults living with HIV. It mainly involves questionnaires, mental health screening, and brain scans, which may help researchers better understand risk factors and brain “underpinnings.”
Miami, FloridaAges 18–59 - NCT06569394RecruitingPhase 2
Testing CBD in young adults who use cannabis heavily
This study tests whether cannabidiol (CBD) can help young adults who use cannabis heavily but aren't looking to quit. You'll take a CBD pill and see if it changes your cannabis use or related symptoms.
Aurora, ColoradoAges 18–25 - NCT07644052RecruitingPhase 3
A medication to ease cannabis withdrawal symptoms
This study tests whether a medication called PP-01 can help reduce cravings and uncomfortable symptoms when people stop using cannabis. If you're a heavy cannabis user who wants to quit and experiences withdrawal symptoms, this trial may help you manage the difficult transition.
Little Rock, ArkansasAges 18–55 - NCT05836207Recruiting
Rewards for quitting cannabis in young adults
This study tests whether offering rewards can help young adults stop using cannabis. You would attend a treatment clinic and provide supervised urine tests twice each week while aiming to quit.
AmsterdamAges 16–22 - NCT06661031Enrolling by invitation
Cannabis use help for young adults via phone app
This study tests a new program that combines telehealth coaching and a smartphone app to help young adults who use cannabis a lot to cut back or quit. If you are a patient at certain Boston clinics and use cannabis on most days, this study might be a good fit for you.
Boston, MassachusettsAges 18–26 - NCT06575751RecruitingPhase 2
Study of cannabidiol and cannabis concentrate users
This study looks at how cannabidiol (a compound in cannabis) affects people who regularly use strong cannabis concentrates like wax, shatter, or oil. It may help understand if using CBD can change how cannabis affects the body or help with cannabis use disorder.
Aurora, ColoradoAges 25–60 - NCT06891235Recruiting
Testing cannabis use with mouth swabs
This study tests whether mouth swabs can detect recent cannabis use. If you use cannabis at least once a week and are between 18 and 30, you may be able to join.
Boston, MassachusettsAges 18–30 - NCT05957848RecruitingPhase 2
Guanfacine for teens with cannabis use problems
This Phase 2 study tests whether extended-release guanfacine can reduce cannabis use in adolescents and young adults. It may help by targeting brain pathways that can drive cravings or continued use.
Parkville, VictoriaAges 12–25 - NCT06395389Recruiting
A brief program to help young adults cut back on cannabis
This trial tests a short, one-time program designed to help people ages 18-25 who use cannabis frequently (at least 20 days per month) reduce their use. It may be a good fit if you're not already in treatment and are thinking about making a change.
Charleston, South CarolinaAges 18–25 - NCT05472818RecruitingEarly Phase 1
Imaging study for treating cannabis use disorder with a test dose
This early-phase study uses brain scans to study cannabis use disorder and looks at whether a treatment approach is suitable for people who use cannabis every day. It may help researchers understand brain changes related to quitting and recovery.
New Haven, ConnecticutAges 18–75 - NCT07157540Enrolling by invitation
Testing Cann'App for cannabis harm reduction
This study is testing a smartphone app called Cann'App to help people who use cannabis reduce related harms. It's only for people who are already in a larger cannabis study in Lausanne, Switzerland.
Lausanne, Vaud CantonAges 18 years+ - NCT03601026Recruiting
Genetic counseling for youth using cannabis safely
This study offers genetic counseling to help reduce mental health problems that can happen for some young people who use cannabis. You join if you are already part of the FORBOW study and fit their age and mental-health criteria.
Halifax, Nova ScotiaAges 12–21 - NCT03995121Recruiting
Brain scan study using a PET tracer
This study tests how a special PET scan tracer behaves in your brain. It may help researchers better understand brain activity and improve imaging for future studies.
New Haven, ConnecticutAges 18–85 - NCT04197921Recruiting
Brain-focused ultrasound for opioid addiction-related substance use
This trial studies Exablate, a non-surgical brain treatment that aims to change activity in a specific brain area involved in cravings and substance use. It is meant for people in structured opioid or substance use treatment who are currently abstaining from opioids and other illicit drugs.
Tampa, FloridaAges 18–60 - NCT04871048Recruiting
tDCS training to reduce cannabis use in people with schizophrenia
This trial tests whether a non-painful brain stimulation method (tDCS) can help people with schizophrenia who also have moderate-to-severe cannabis use disorder reduce or quit cannabis. It also involves MRI scanning to help study brain changes.
BronAges 18–60 - NCT05389930RecruitingPhase 2
Study how cannabis affects alcohol drinking
This Phase 2 study looks at whether using cannabis changes how much alcohol you drink. You may be able to take part if you’ve been drinking heavily and using cannabis recently and can meet health and screening requirements.
Providence, Rhode IslandAges 21–50 - NCT05445180Recruiting
Brain scan study of thinking in cannabis users with psychosis
This study uses brain imaging to understand how thinking works in people who use cannabis, comparing those with psychosis to people without psychosis. It may help researchers learn what brain patterns relate to thinking difficulties and how cannabis use fits in.
Montreal, QuebecAges 16–80 - NCT05704582Recruiting
Avatar vs supportive sessions to cut cannabis use
This study compares two types of talking/learning sessions—one using an “avatar” (computer-based character) and one using regular supportive sessions—to reduce cannabis use. It is meant for adults with psychotic disorders who also meet criteria for cannabis use disorder.
Montreal, QuebecAges 18 years+ - NCT05729932RecruitingPhase 1
Cannabis and opioid use disorder study
This Phase 1 trial studies cannabis in people with opioid use disorder. The goal is to better understand how it may affect opioid use disorder, while monitoring safety.
Lexington, KentuckyAges 18–55
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Cannabis Use Disorder trials by city
Studies with a site in or near these metro areas.
Cannabis Use Disorder trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for cannabis use disorder?
- Yes. Clin2 currently lists 155 recruiting cannabis use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cannabis use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cannabis use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.