Clinical trials
Cannabis Use Disorder clinical trials
Below are recruiting cannabis use disorder clinical trials, each written for real people, not researchers. We’re tracking 150 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05704582Recruiting
Avatar vs supportive sessions to cut cannabis use
This study compares two types of talking/learning sessions—one using an “avatar” (computer-based character) and one using regular supportive sessions—to reduce cannabis use. It is meant for adults with psychotic disorders who also meet criteria for cannabis use disorder.
Montreal, QuebecAges 18 years+ - NCT06084520Recruiting
Pain questionnaire study for opioid and non-opioid patients
This study tests two questionnaires for people with long-term pain. Researchers want to see if the tools work well for both those taking opioids and those who are not. Your answers can help improve pain care.
Uppsala, UpplandAges 18–75 - NCT07644052RecruitingPhase 3
Study of a new medicine to ease cannabis withdrawal
This study tests a new medicine, PP-01, to help adults who use cannabis daily and want to quit. It aims to reduce withdrawal symptoms like anxiety, irritability, and sleep problems during the first week after stopping.
Little Rock, ArkansasAges 18–55 - NCT06701487Recruiting
Brain learning mechanisms and substance use control
This study looks at how certain learning mechanisms in the brain (called Pavlovian conditioning) influence your ability to control alcohol or drug use. It may help explain why some people have trouble stopping, and could lead to better treatments. You'll fill out questionnaires and likely have a brain scan (MRI).
DresdenAges 18–65 - NCT07523633RecruitingPhase 2
Semaglutide to help reduce cannabis use disorder
This trial tests whether a medication called semaglutide (used for weight management) can help adults with cannabis use disorder cut down or stop using cannabis. Researchers want to see if it reduces cravings and use while also monitoring overall health.
FrederiksbergAges 18–70 - NCT07340554Recruiting
Brain imaging study for teens who use cannabis
This study looks at the brains of teenagers who use cannabis using an MRI scanner. It aims to understand how cannabis affects the developing brain, which might help improve treatment options.
Indianapolis, IndianaAges 14–17 - NCT07184983Recruiting
Brain stimulation for cannabis use disorder
This study tests whether a gentle brain stimulation technique (called tDCS) can help people who want to cut down or stop using cannabis. You'll wear a headband-like device during sessions at NYU, and the study team will check in with you over time.
New York, New YorkAges 22–65 - NCT07157540Enrolling by invitation
Testing Cann'App for cannabis harm reduction
This study is testing a smartphone app called Cann'App to help people who use cannabis reduce related harms. It's only for people who are already in a larger cannabis study in Lausanne, Switzerland.
Lausanne, Vaud CantonAges 18 years+ - NCT03601026Recruiting
Genetic counseling for youth using cannabis safely
This study offers genetic counseling to help reduce mental health problems that can happen for some young people who use cannabis. You join if you are already part of the FORBOW study and fit their age and mental-health criteria.
Halifax, Nova ScotiaAges 12–21 - NCT07091292Recruiting
Exercise as a treatment for cannabis use
This study tests whether regular exercise can help young adults reduce or stop their cannabis use. It may be a good fit if you are 18-40, use cannabis as your main drug, and want to try an exercise-based approach.
Hong KongAges 18–40 - NCT07071779Recruiting
Online training to help young people resist alcohol or cocaine
This study tests a web-based training program to help teens and young adults (ages 14–35) improve their ability to say no to alcohol or cocaine. The training could make it easier to resist cravings during treatment.
BernAges 14–35 - NCT07056894Recruiting
Cognitive training for substance use in early psychosis
This study tests a computer-based cognitive training program to help people with early psychosis reduce their alcohol and cannabis use. The program is designed to improve thinking skills and may make it easier to cut back on substance use.
St. John's, Newfoundland and LabradorAges 16–30 - NCT06981195RecruitingPhase 2
Testing lemborexant for insomnia in people on buprenorphine
This study tests if the sleep medication lemborexant can help people with opioid use disorder who also have chronic insomnia. Participants must already be taking buprenorphine (Suboxone) for at least 4 weeks. The goal is to see if better sleep improves mood and reduces opioid use.
Richmond, VirginiaAges 18 years+ - NCT06891235Recruiting
Oral fluid testing for cannabis use in young adults
This study is testing a new way to check for recent cannabis use using a quick oral fluid (saliva) test, instead of a traditional urine test. You may be able to help if you're a young adult who uses cannabis regularly.
Boston, MassachusettsAges 18–30 - NCT06883162RecruitingPhase 3
A study to help people stop smoking tobacco and reduce cannabis use
This study tests whether a medication called varenicline (or a placebo) can help people who use both tobacco and cannabis to quit or cut back. It takes place in South Carolina and lasts 12 weeks.
Charleston, South CarolinaAges 18 years+ - NCT06878859Recruiting
Online program for depression and cannabis use
This study tests a digital (online) program designed to help people who struggle with both depression and cannabis use. If you're feeling down and also using cannabis more than you'd like, this program might help you manage both.
Boston, MassachusettsAges 18 years+ - NCT05836207Recruiting
Rewards for quitting cannabis in young adults
This study tests whether offering rewards can help young adults stop using cannabis. You would attend a treatment clinic and provide supervised urine tests twice each week while aiming to quit.
AmsterdamAges 16–22 - NCT05957848RecruitingPhase 2
Guanfacine for teens with cannabis use problems
This Phase 2 study tests whether extended-release guanfacine can reduce cannabis use in adolescents and young adults. It may help by targeting brain pathways that can drive cravings or continued use.
Parkville, VictoriaAges 12–25 - NCT06661031Enrolling by invitation
Cannabis use help for young adults via phone app
This study tests a new program that combines telehealth coaching and a smartphone app to help young adults who use cannabis a lot to cut back or quit. If you are a patient at certain Boston clinics and use cannabis on most days, this study might be a good fit for you.
Boston, MassachusettsAges 18–26 - NCT06660381RecruitingPhase 1
Psilocybin therapy for cannabis use disorder
This study tests if psilocybin (a substance that can change how you think and feel) can help people reduce or stop using cannabis. You will receive support and be monitored closely throughout the trial.
Baltimore, MarylandAges 18 years+ - NCT06609083RecruitingPhase 1
How cannabis affects cigarette smoking
This study looks at how cannabis affects cigarette smoking habits. If you smoke every day and also use cannabis weekly, researchers want to see if cannabis changes how much you smoke.
Baltimore, MarylandAges 21 years+ - NCT06609109RecruitingPhase 1
Testing how cannabis affects e-cigarette use
This study is for daily e-cigarette users who also use cannabis at least once a week. It tests how cannabis affects vaping behavior. Researchers want to see if using cannabis changes how much or how people vape.
Baltimore, MarylandAges 21 years+ - NCT06575751RecruitingPhase 2
Study of cannabidiol and cannabis concentrate users
This study looks at how cannabidiol (a compound in cannabis) affects people who regularly use strong cannabis concentrates like wax, shatter, or oil. It may help understand if using CBD can change how cannabis affects the body or help with cannabis use disorder.
Aurora, ColoradoAges 25–60 - NCT06569394RecruitingPhase 2
Testing CBD in young adults who use cannabis heavily
This study tests whether cannabidiol (CBD) can help young adults who use cannabis heavily but aren't looking to quit. You'll take a CBD pill and see if it changes your cannabis use or related symptoms.
Aurora, ColoradoAges 18–25
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Cannabis Use Disorder trials by city
Studies with a site in or near these metro areas.
Cannabis Use Disorder trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for cannabis use disorder?
- Yes. Clin2 currently lists 150 recruiting cannabis use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cannabis use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cannabis use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.