Regenerative medicine for joint looseness and instability
Treatments studied
Part of Blood & lymphatic, Bones, joints & muscles, Genetic & congenital, Heart & circulation, Injuries & trauma, Pain, Skin clinical trials.
This study tests a regenerative medicine approach for people with joint looseness (hypermobility) or instability that causes long-term pain. It uses injections (like dextrose, platelet-rich plasma, or a medication called doxycycline) to help strengthen the joint and reduce pain.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 or older.
- You have joint looseness (hypermobility) or instability from a condition like Ehlers-Danlos syndrome (hypermobile type) or a previous joint injury.
- The joint problem has caused pain for at least 3 months, and your average pain is 4 or more on a 0–10 scale.
- You have already tried physical therapy for at least 6 weeks and it didn't fully help.
- You are not currently taking anti-inflammatory pain relievers (NSAIDs) like ibuprofen or naproxen, and are willing to avoid them during treatment.
- You do not have active infection, allergies to the study drugs, uncontrolled diabetes, a joint replacement in the affected joint, or are pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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