Steroid avoidance and new drug for brain tumor swelling
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This trial tests a drug called azeliragon to see if it can reduce brain swelling after surgery for a high-grade glioma, while avoiding steroids like dexamethasone. If you have a newly diagnosed brain tumor and are scheduled for surgery to remove most of it, this study may offer an alternative to standard steroid treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have a newly diagnosed brain tumor in the upper part of your brain that looks like a high-grade glioma on scans
- You are scheduled for surgery to remove more than half of the tumor that shows up on contrast MRI
- The midline of your brain is shifted less than 10 millimeters on your last scan
- You have taken little or no steroid medicine (10 mg or less of dexamethasone total, and no regular steroid use in the last 30 days)
- You are healthy enough for surgery and can follow the study plan
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
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This trial tests how to best use dexamethasone (a steroid) after brain tumor surgery to help recovery and reduce swelling. It looks at different dosing schedules for patients with common brain tumors.
This trial tests whether adding the study drug azeliragon to standard radiation and chemotherapy can help people with newly diagnosed glioblastoma. The study will also look at how the tumor responds to the added drug.
This trial tests if a drug called disulfiram (normally used for alcohol abuse) can help reduce immune suppression caused by the tumor and lower the need for steroids in people with a fast-growing brain tumor who are about to have surgery. It aims to see if taking the drug before surgery improves outcomes.
This trial tests a new drug called FPS-ZM1, with or without a steroid (dexamethasone), to see if it helps control brain swelling after surgery for glioblastoma. You will take the study drug before and after your planned surgery, and the study will check how safe and effective it is.
This trial tests a new drug called ADI-PEG 20 combined with standard treatments (temozolomide and radiation) for children and young adults with newly diagnosed high-grade glioma. It aims to see if this combination is safe and effective.
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