Disulfiram before brain tumor surgery to reduce steroid need
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This trial tests if a drug called disulfiram (normally used for alcohol abuse) can help reduce immune suppression caused by the tumor and lower the need for steroids in people with a fast-growing brain tumor who are about to have surgery. It aims to see if taking the drug before surgery improves outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You have a high-grade glioma (a fast-growing brain tumor) that will be surgically removed as part of your usual care.
- You can start taking the study drug (disulfiram) at least 3 days before your surgery and up to 14 days before.
- You must be in the hospital for the whole study.
- Your blood counts and liver function must be within a certain healthy range.
- You cannot have taken any steroids for brain swelling before starting the study, and you must avoid alcohol completely.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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