Disulfiram before brain tumor surgery to reduce need for steroids
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This study tests whether a drug called disulfiram (commonly used for alcohol aversion) can help reduce immune suppression in the body and decrease the need for steroids in people with a high-grade brain tumor who are scheduled for surgery. Taking disulfiram before surgery may help the immune system fight the tumor better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have a high-grade glioma (a type of brain tumor) and be scheduled for surgery to remove it as part of your standard care.
- You need to be able to start taking the study drug at least 3 days before your planned surgery, and you'll need to stay in the hospital for the study.
- You must be generally healthy enough to carry out daily activities (Karnofsky score of 70% or higher).
- You must not have used steroids (like dexamethasone) to treat brain swelling before starting this trial.
- You must agree to avoid all alcohol and products containing alcohol during treatment and for 14 days after your last dose.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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