Study of Linzagolix for adenomyosis and repeated IVF failure
Part of Women’s health & pregnancy clinical trials.
This trial tests if linzagolix can help women with adenomyosis who have had two or more failed embryo transfers. It aims to improve the chance of a successful pregnancy in a future transfer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 50 years old.
- You have adenomyosis, diagnosed by ultrasound or MRI.
- You have had at least two failed embryo transfers with good-quality embryos (graded BB or higher, or genetically normal).
- You have at least one embryo available for transfer that is graded BB or higher or genetically normal.
- Your uterus has a normal shape with no large fibroids or polyps blocking the cavity.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether adding letrozole (a medication that lowers estrogen) to standard hormone therapy helps women with adenomyosis have a better chance of pregnancy during in vitro fertilization (IVF). If you have adenomyosis and are planning an IVF cycle with one embryo transfer, this study may be a good fit.
This study tests an oral medication (linzagolix) versus an injectable medication commonly used to control the timing of ovulation during IVF or ICSI. The goal is to see if the oral option works as well as the injection, making treatment simpler for patients.
This trial studies whether adjusting the length of pre-treatment with a hormone blocker (GnRH agonist) and adding letrozole before a frozen embryo transfer can improve pregnancy outcomes for people with adenomyosis.
This trial tests if the drug nintedanib can improve pregnancy rates in women with adenomyosis who are undergoing IVF. It is for women who have at least one high-quality frozen embryo and want to see if this medication helps the embryo implant successfully.
This trial studies whether giving a GnRH “downshifting” shot before transferring a frozen embryo can improve pregnancy outcomes for people with endometriosis or adenomyosis. It may help by changing hormone activity before the transfer.
This study tests if a medicine called letrozole can help prepare the lining of the womb for a frozen embryo transfer. It may be an option for women under 40 who have had limited previous IVF cycles.
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