Linzagolix for adenomyosis and repeated IVF failure
Part of Women’s health & pregnancy clinical trials.
This trial tests a medicine called linzagolix for people with adenomyosis (a condition where the uterine lining grows into the muscle wall) who have had two or more failed IVF attempts. The medicine may help by reducing the adenomyosis, potentially improving the chance of a successful embryo transfer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 50 years old.
- You have been diagnosed with adenomyosis (confirmed by ultrasound or MRI).
- You have had at least 2 failed embryo transfers with high-quality embryos (blastocysts graded BB or better).
- You have at least one good-quality embryo (graded BB or better) available for transfer.
- You have a normal uterine cavity (no large fibroids or polyps blocking the cavity).
- You have not had prior treatment with linzagolix or GnRH analogues (like Lupron) in the last 6 months.
- Your BMI is 35 or less.
- You do not have untreated hydrosalpinx (fluid-filled fallopian tube), untreated stage III–IV endometriosis, or a major uterine anomaly (like a uterine septum).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether adding a medicine called letrozole to standard hormone therapy improves the chances of pregnancy in women with adenomyosis who are doing IVF. Adenomyosis is a condition where tissue that normally lines the womb grows into the womb muscle, which can affect fertility.
This trial compares two ways of taking a medication that helps control your hormones during IVF (in vitro fertilization), one as a pill and one as an injection, to see if the pill works just as well. It also includes a third group who get a different type of hormone treatment. This could help make IVF more convenient for you.
This trial tests whether giving a hormone-lowering drug for a longer time before frozen embryo transfer, plus adding a hormone pill (letrozole), improves success for people with adenomyosis. It aims to help those with this womb condition have a better chance of a successful pregnancy.
This trial studies whether giving a GnRH “downshifting” shot before transferring a frozen embryo can improve pregnancy outcomes for people with endometriosis or adenomyosis. It may help by changing hormone activity before the transfer.
This trial tests whether giving extra luteinizing hormone (LH) can improve embryo quality in women with very low LH levels during IVF. It may help you if you have low LH and are using a specific type of fertility medication.
This study tests whether taking a medication called nintedanib before embryo transfer improves pregnancy chances in women with adenomyosis. Nintedanib may help by reducing inflammation and abnormal blood vessels in the uterus linked to adenomyosis.
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