Comparing two steroids for adrenal insufficiency after long-term steroid use
Treatments studied
Part of Hormones & metabolism clinical trials.
This trial compares two steroid medicines (hydrocortisone and methylprednisolone) to see which one works better for people whose adrenal glands have stopped working properly after taking high doses of steroids for a long time. It aims to find the safest and most effective way to replace the missing hormones.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are over 18 years old.
- You have been taking methylprednisolone 4 mg every day for at least the last 4 weeks.
- You have been taking high doses of methylprednisolone for more than 4 weeks in total.
- Your morning cortisol level is low (below 300 nmol/L).
- You have had a short ACTH test that shows your adrenal glands are not responding properly.
- You do not need to continue steroid treatment for the original condition, and you are not expected to need steroids again in the next 2 years.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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